Vision – Non Invasive Prenatal Test
Vision is a highly sensitive prenatal test that can be carried out as early as 10 weeks into pregnancy, using a single blood sample. Vision measures the baby’s DNA that circulates in the mother’s blood during pregnancy, checking the number of chromosome copies which can be related to conditions such as:
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- Who can take this test?
- What are the differences with the anomalies detected by an amniocentesis?
- Can the NACE® test be done with donated oocytes? What about when using a surrogate uterus?
- Can the study be done in twin gestations?
- What happens if a NACE® test gives a positive result?
- What happens if the fetal sex result from the NACE® test isn’t the same as the ultrasound results?
- What is NACE?
- What is NACE 24?
- What is NACE Extended 24?
These tests are recommended for women who want to rule out the most commonly detected fetal chromosomal alterations without putting their pregnancy at risk. They are especially recommended for women with a high risk of chromosomal abnormalities after first trimester screening, those with previous Down syndrome pregnancies, or to detect any alterations suspected from ultrasounds.
At the chromosomal level, NACE® detects anomalies in the number of chromosomes, not in their structure. It only detects anomalies for a limited number of chromosomes related with problems in gestations after the second trimester of pregnancy.
Yes, the test can be done in both cases.
Yes, the NACE® test can be done, bearing in mind that in these cases we cannot provide information on the fetal sexes, or about any alterations in sexual chromosomes; the test only informs about the presence or the absence of a Y chromosome.
An amniocentesis or chorionic villus biopsy should be carried out. Occasionally, in cases of arrested pregnancy conventional curettage is performed. The chromosomal analysis preformed depends on the alteration found and may be:
- Conventional karyotype: which will serve to confirm/discard complete or partial aneuploidies in any chromosome as well as results suggestive of mosaicism.
- Quantitative fluorescent polymerase chain reaction (QF-PCR): to discard/confirm aneuploidies of chromosomes 13, 18, 21, or sexual chromosomes.
- Fluorescent in situ hybridization (FISH) and/or short tandem repeat (STR) analysis: to discard/confirm aneuploidies of chromosomes 9 or 16.
- FISH and/or microarray-based comparative genomic hybridization (array CGH): to discard/confirm some microdeletions.
A new maternal blood sample should be taken in a Streck tube and the Igenomix laboratories will determine the fetal sex (free of charge).
- NACE is a non-invasive prenatal screening test that analyzes the most frequent chromosomal alterations without compromising the pregnancy.
- NACE is a complete prenatal test to detect anomalies in chromosomes 21, 18, and 13 (Down, Edwards, and Patau syndromes). It also detects the most common anomalies in the sexual chromosomes (X and Y)*.
NACE 24 test has all the features of the non-invasive prenatal test, with an extended version incorporating trisomy detection for all 24 chromosomes.
NACE Extended 24 has the same characteristics as the NACE test, but is an extended version that also incorporates the detection of all 24 chromosomes and identifies five microdeletions which are associated with major genetic syndromes: DiGeorge syndrome, 1p36 deletion syndrome, Angelman syndrome**, Prader-Willi syndrome**, Cri-du-chat syndrome, and Wolf-Hirschhorn syndrome..